Nano-molecularly imprinted polymers for serum creatinine sensing using the heat transfer method

Serum creatinine concentration is an important clinical measure of kidney function. However, standard methods detection, such as the Jaffe method or enzymatic assays, suffer several disadvantages, including non-specificity and procedural complexity, high cost, respectively. In this work, we propose use nano-molecularly imprinted polymers (nMIPs) in conjunction with novel Heat Transfer Method (HTM) a promising alternative sensing platform to these existing for measuring serum concentration. More specifically, it shown that creatinine-imprinted nMIPs can be produced using solid-phase templating method, simple drop-casting onto cheap, disposable substrate used HTM detect limit-of-detection (7.0 ± 0.5) μM buffer solutions. Furthermore, are selectively bind comparison similar molecules, demonstrated able changes complex blood plasma samples.